She was born in 1956 in Skaryszew in the Radom region.
She is a graduate of the Faculty of Medicine of the Medical Academy in Lublin. She has the second degree of specialisation in paediatrics and specialisation in family medicine. Until 2001 she was in charge of the Health Care Centre in Szydłowiec.
In the years 1998-2001, she held the position of a Mazovian Regional Assembly councillor.
Since 2001 Ms Kopacz has been a member of Civic Platform. On behalf of this party she was an MP of Sejm's 4th term, representing the Radom constituency. She was subsequently elected MP for Sejm's 5th term, in which she held the position of the Health Committee's chair.
Since 10 October 2010 she has been Civic Platform's deputy chair. In the 2007 parliamentary election, she obtained the MP's mandate for the third time, and on 16 November 2007 was appointed Minister of Health.
In the 2011 election, she became an MP of Sejm's 7th term. On 8 November 2011, she was elected Sejm's Speaker.
Her daughter Katarzyna is a doctor, a graduate of the Medical Academy in Gdańsk.